产品名称
PPM1E Rabbit Polyclonal Antibody
基因名称
PPM1E CAMKN KIAA1072 POPX1
蛋白名称
Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8WY54
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8WY54/entry
Mouse Swissprot No.
Q80TL0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80TL0
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q80Z30
免疫原
Synthesized peptide derived from human protein . at AA range: 460-540
特异性
PPM1E Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012],
细胞定位
Nucleus . Cytoplasm . A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full-length, minor form, is found in the nucleus. .
功能
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 2 magnesium or manganese ions per subunit.,function:Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain.,subcellular location:A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full length, minor form, is found in the nucleus.,subunit:Heterotrimer. Interacts with PAX1 and ARHGEF6 (or ARHGEF7).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
