产品名称
HDGF2 Rabbit Polyclonal Antibody
基因名称
HDGFRP2 HDGF2 UNQ785/PRO1604
蛋白名称
Hepatoma-derived growth factor-related protein 2 (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84717
Human Swissprot No.
Q7Z4V5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q7Z4V5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15193
Mouse Swissprot No.
Q3UMU9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UMU9/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171073
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q925G1/entry
特异性
This antibody detects endogenous levels of HDGF2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. High expression is found in heart, skeletal muscle, ovary and testis. Overexpression is frequently observed in hepatocellular carcinoma samples.
细胞定位
Nucleus . Cytoplasm .
功能
Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) . Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters . Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs . Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 . Involved in cellular growth control, through the regulation of cyclin D1 expression .
