产品名称
TRIM32 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase TRIM32 (EC 6.3.2.-) (72 kDa Tat-interacting protein) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22954
Human Swissprot No.
Q13049
Human Swissprot Link
https://www.uniprot.org/uniprot/Q13049
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=69807
Mouse Swissprot No.
Q8CH72
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CH72/entry
特异性
This antibody detects endogenous levels of TRIM32 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle.
细胞定位
Cytoplasm . Localized in cytoplasmic bodies, often located around the nucleus. .
功能
Has an E3 ubiquitin ligase activity . Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation . May ubiquitinate BBS2 . Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation . ; (Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo . Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo .
