产品名称
YTHDC2 Rabbit Polyclonal Antibody
蛋白名称
Probable ATP-dependent RNA helicase YTHDC2 (EC 3.6.4.13)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64848
Human Swissprot No.
Q9H6S0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H6S0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=240255
Mouse Swissprot No.
B2RR83
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/B2RR83/entry
特异性
This antibody detects endogenous levels of YTHDC2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in testis (PubMed:29087293). Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis (PubMed:29087293).
细胞定位
Cytoplasm . Cytoplasm, perinuclear region .
功能
3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells . Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability . Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease . Required for both spermatogenesis and oogenesis (By similarity).
