产品名称
FBL Rabbit Polyclonal Antibody
蛋白名称
rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2091
Human Swissprot No.
P22087
Human Swissprot Link
https://www.uniprot.org/uniprot/P22087
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100044829
Mouse Swissprot No.
P35550
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P35550/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=292747
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P22509/entry
特异性
This antibody detects endogenous levels of FBL at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus, nucleolus . Nucleus, nucleoplasm . Fibrillar region of the nucleolus.
功能
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins . Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA . Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes . U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity . Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus .
