产品名称
PDIA6 Rabbit Polyclonal Antibody
基因名称
PDIA6 ERP5 P5 TXNDC7
蛋白名称
Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10130
Human Swissprot No.
Q15084
Human Swissprot Link
https://www.uniprot.org/uniprot/Q15084
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=71853
Mouse Swissprot No.
Q922R8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q922R8/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=286906
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63081/entry
特异性
This antibody detects endogenous levels of PDIA6 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in platelets (at protein level).
细胞定位
Endoplasmic reticulum lumen . Cell membrane . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). .
功能
May function as a chaperone that inhibits aggregation of misfolded proteins . Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling . May also regulate the UPR via the EIF2AK3 UPR sensor . Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin .
