产品名称
LARP7 Rabbit Polyclonal Antibody
蛋白名称
La-related protein 7 (La ribonucleoprotein domain family member 7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51574
Human Swissprot No.
Q4G0J3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q4G0J3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=28036
Mouse Swissprot No.
Q05CL8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q05CL8/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=686883
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5XI01/entry
特异性
This antibody detects endogenous levels of LARP7 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus, nucleoplasm .
功能
RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function . Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II . The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation . The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) . LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex . LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing . Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes . U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity . Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif . U6 snRNA processing is required for spermatogenesis (By similarity).
