产品名称
ASGR1 Rabbit Polyclonal Antibody
蛋白名称
Asialoglycoprotein receptor 1 (ASGP-R 1) (ASGPR 1) (C-type lectin domain family 4 member H1) (Hepatic lectin H1) (HL-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=432
Human Swissprot No.
P07306
Human Swissprot Link
https://www.uniprot.org/uniprot/P07306
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11889
Mouse Swissprot No.
P34927
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P34927/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24210
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P02706/entry
特异性
This antibody detects endogenous levels of ASGR1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed exclusively in hepatic parenchymal cells.
细胞定位
[Isoform H1a]: Membrane; Single-pass type II membrane protein.; [Isoform H1b]: Secreted .
功能
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
