产品名称
THAP1 Rabbit Polyclonal Antibody
蛋白名称
THAP domain-containing protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55145
Human Swissprot No.
Q9NVV9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NVV9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=73754
Mouse Swissprot No.
Q8CHW1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CHW1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=306547
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U208/entry
特异性
This antibody detects endogenous levels of THAP1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta.
细胞定位
Nucleus, nucleoplasm . Nucleus, PML body .
功能
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
