产品名称
DNAJC10 Rabbit Polyclonal Antibody
基因名称
DNAJC10 ERDJ5 UNQ495/PRO1012
蛋白名称
DnaJ homolog subfamily C member 10 (ER-resident protein ERdj5) (Macrothioredoxin) (MTHr)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54431
Human Swissprot No.
Q8IXB1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8IXB1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66861
Mouse Swissprot No.
Q9DC23
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DC23/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=295690
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q498R3/entry
特异性
This antibody detects endogenous levels of DNAJC10 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endoplasmic reticulum lumen .
功能
Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.
