产品名称
GEFT Rabbit Polyclonal Antibody
蛋白名称
Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=115557
Human Swissprot No.
Q86VW2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q86VW2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=52666
Mouse Swissprot No.
Q9CWR0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CWR0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=314904
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P720/entry
特异性
This antibody detects endogenous levels of GEFT at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver.
细胞定位
Cell membrane . Cytoplasm, myofibril, sarcomere . Highly colocalizes with actin regions.
功能
May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity).
