产品名称
Choline Kinase Alpha Rabbit Polyclonal Antibody
蛋白名称
Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK-alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1119
Human Swissprot No.
P35790
Human Swissprot Link
https://www.uniprot.org/uniprot/P35790
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12660
Mouse Swissprot No.
O54804
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O54804/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29194
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q01134/entry
特异性
This antibody detects endogenous levels of Choline Kinase Alpha at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm, cytosol .; [Isoform 1]: Lipid droplet . Isoform 1 localizes to lipid droplets following phosphorylation by AMPK. .
功能
Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis . Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis . Has higher activity with choline . May contribute to tumor cell growth . ; [Isoform 1]: This isoform plays a key role in lipolysis of lipid droplets following glucose deprivation . In response to glucose deprivation, phosphorylated by AMPK, promoting localization to lipid droplets . Phosphorylation is followed by acetylation by KAT5, leading to dissociation of the homodimer into a monomer . Monomeric CHKA isoform 1 is converted into a tyrosine-protein kinase, which phosphorylates lipid droplet structural proteins PLIN2 and PLIN3, leading to lipolysis of lipid droplets .
