产品名称
CCP1 Rabbit Polyclonal Antibody
基因名称
AGTPBP1 CCP1 KIAA1035 NNA1
蛋白名称
Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23287
Human Swissprot No.
Q9UPW5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UPW5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67269
Mouse Swissprot No.
Q641K1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q641K1/entry
特异性
This antibody detects endogenous levels of CCP1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Cytoplasm, cytosol . Nucleus . Mitochondrion . Localizes in both the cytoplasm and nuclei of interphase and dividing cells. .
功能
Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins . Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin . Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate . Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK . Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis .
