产品名称
IFT25 Rabbit Polyclonal Antibody
基因名称
HSPB11 C1orf41 HSPC034
蛋白名称
Heat shock protein beta-11 (Hspb11) (Placental protein 25) (PP25)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51668
Human Swissprot No.
Q9Y547
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y547
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72938
Mouse Swissprot No.
Q9D6H2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D6H2/entry
特异性
This antibody detects endogenous levels of IFT25 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in placenta.
细胞定位
Cell projection, cilium .
功能
Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity).
