产品名称
MIG6; ERRFI1 Rabbit Polyclonal Antibody
蛋白名称
ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54206
Human Swissprot No.
Q9UJM3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UJM3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74155
Mouse Swissprot No.
Q99JZ7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99JZ7/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=313729
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P05432/entry
特异性
This antibody detects endogenous levels of MIG6; ERRFI1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Nucleus . Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity). .
功能
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).
