BD-PN5838

DDRGK1 Rabbit Polyclonal Antibody

常规抗体

DDRGK1 C20orf116

DDRGK domain-containing protein 1

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

65992

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65992

Q96HY6

https://www.uniprot.org/uniprot/Q96HY6

77006

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=77006

Q80WW9

https://www.uniprot.org/uniprotkb/Q80WW9/entry

This antibody detects endogenous levels of DDRGK1 at Human, Mouse

WB 1:500-2000

35kD

-15°C to -25°C/1 year(Do not lower than -25°C)

Widely expressed (at protein level). In the brain, highest levels in medulla oblongata, followed by cerebral cortex, cerebellum and frontal lobe.

Endoplasmic reticulum . Endoplasmic reticulum membrane . Localizes to the endoplasmic reticulum membrane in response to endoplasmic reticulum stress. .

Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy) . In response to endoplasmic reticulum stress, promotes recruitment of the E3 UFM1-protein ligase UFL1 to the endoplasmic reticulum membrane: in turn, UFL1 mediates ufmylation of proteins such as RPN1 and RPL26/uL24, promoting reticulophagy of endoplasmic reticulum sheets . Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability . Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis or inflammatory response (By similarity). Required for TRIP4 ufmylation, thereby regulating nuclear receptors-mediated. transcription . May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B . Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator .

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