产品名称
ACTN4 Rabbit Polyclonal Antibody
蛋白名称
Alpha-actinin-4 (F-actin cross-linking protein) (Non-muscle alpha-actinin 4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81
Human Swissprot No.
O43707
Human Swissprot Link
https://www.uniprot.org/uniprot/O43707
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60595
Mouse Swissprot No.
P57780
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P57780/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=63836
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QXQ0/entry
特异性
This antibody detects endogenous levels of ACTN4 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Cytoplasm . Cell junction . Cytoplasm, cytoskeleton, stress fiber . Cytoplasm, perinuclear region . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity). Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC-2, and bladder cancer KU-7). .
功能
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation . Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA .
