产品名称
FATP2 Rabbit Polyclonal Antibody
基因名称
SLC27A2 ACSVL1 FACVL1 FATP2 VLACS
蛋白名称
Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11001
Human Swissprot No.
O14975
Human Swissprot Link
https://www.uniprot.org/uniprot/O14975
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26458
Mouse Swissprot No.
O35488
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35488/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65192
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P97524/entry
特异性
This antibody detects endogenous levels of FATP2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in liver, kidney, placenta and pancreas.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Peroxisome membrane ; Peripheral membrane protein . Cell membrane ; Multi-pass membrane protein . Microsome .
功能
Acyl CoA synthetase that activates long-chain and very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA . Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid . Does not activate C24 bile acids, cholate and chenodeoxycholate . In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol . Exhibits long-chain fatty acids (LCFA) transport activity and plays an important role in hepatic fatty acid uptake . ; [Isoform 1]: Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids . Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol . ; [Isoform 2]: Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids.
