产品名称
INO80 Rabbit Polyclonal Antibody
基因名称
INO80 INO80A INOC1 KIAA1259
蛋白名称
DNA helicase INO80 (hINO80) (EC 3.6.4.12) (INO80 complex subunit A) (Putative DNA helicase INO80 complex homolog 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54617
Human Swissprot No.
Q9ULG1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9ULG1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=68142
Mouse Swissprot No.
Q6ZPV2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6ZPV2/entry
特异性
This antibody detects endogenous levels of INO80 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas.
细胞定位
Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle . Chromosome . Localizes to the cytoplasm in quiescent cell (PubMed:20237820). Associates with spindle microtubules during mitosis (PubMed:20237820). Colocalizes with PCNA at replication forks during S-phase (PubMed:20237820). Recruited to DNA damage sites in a ACTR8-dependent manner (PubMed:20971067). .
功能
ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair . Binds DNA . As part of the INO80 complex, remodels chromatin by shifting nucleosomes . Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator . Involved in UV-damage excision DNA repair . The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation . Involved in DNA replication . Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle .
