产品名称
FAM134B Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54463
Human Swissprot No.
Q9H6L5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H6L5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66270
Mouse Swissprot No.
Q8VE91
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VE91/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=619558
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5FVM3/entry
特异性
This antibody detects endogenous levels of FAM134B at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Overexpressed in esophageal squamous cell carcinoma (PubMed:17487424).
细胞定位
Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes . Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins . Required for long-term survival of nociceptive and autonomic ganglion neurons .
