产品名称
VDAC2 Rabbit Polyclonal Antibody
蛋白名称
Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7417
Human Swissprot No.
P45880
Human Swissprot Link
https://www.uniprot.org/uniprot/P45880
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22334
Mouse Swissprot No.
Q60930
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60930/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83531
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P81155/entry
特异性
This antibody detects endogenous levels of VDAC2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in erythrocytes (at protein level) (PubMed:27641616). Expressed in all tissues examined (PubMed:8420959).
细胞定位
Mitochondrion outer membrane . Membrane . May localize to non-mitochondrial membranes. .
功能
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol . Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway .
