产品名称
NELFE Rabbit Polyclonal Antibody
蛋白名称
Negative elongation factor E (NELF-E) (RNA-binding protein RD)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7936
Human Swissprot No.
P18615
Human Swissprot Link
https://www.uniprot.org/uniprot/P18615
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27632
Mouse Swissprot No.
P19426
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P19426/entry
特异性
This antibody detects endogenous levels of NELFE at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.
细胞定位
Nucleus . Chromosome . Localizes to chromatin (PubMed:14701750). Phosphorylation by the P-TEFb complex promotes its release from chromatin (PubMed:14701750). .
功能
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II . The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex . Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA . ; (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.
