产品名称
IFT57 Rabbit Polyclonal Antibody
基因名称
IFT57 DERP8 ESRRBL1 HIPPI
蛋白名称
Intraflagellar transport protein 57 homolog (Dermal papilla-derived protein 8) (Estrogen-related receptor beta-like protein 1) (HIP1-interacting protein) (MHS4R2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55081
Human Swissprot No.
Q9NWB7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NWB7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=73916
Mouse Swissprot No.
Q8BXG3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BXG3/entry
特异性
This antibody detects endogenous levels of IFT57 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level).
细胞定位
Cytoplasm, cytoskeleton, cilium basal body . Concentrates within the inner segment of cilia. .
功能
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
