产品名称
GOLPH3 Rabbit Polyclonal Antibody
蛋白名称
Golgi phosphoprotein 3 (Coat protein GPP34) (Mitochondrial DNA absence factor) (MIDAS)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64083
Human Swissprot No.
Q9H4A6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H4A6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66629
Mouse Swissprot No.
Q9CRA5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CRA5/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ERE4/entry
特异性
This antibody detects endogenous levels of GOLPH3 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in muscle fibers of patients with mitochondrial diseases; not detected in normal muscle fibers.
细胞定位
Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion intermembrane space. Cell membrane . Endosome . Phosphatidylinositol 4-phosphate-binding and oligomerization participate in the recruitment onto Golgi membranes. .
功能
Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis.
