产品名称
RPGRIP1L Rabbit Polyclonal Antibody
基因名称
RPGRIP1L FTM KIAA1005 NPHP8
蛋白名称
Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23322
Human Swissprot No.
Q68CZ1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q68CZ1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=244585
Mouse Swissprot No.
Q8CG73
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CG73/entry
特异性
This antibody detects endogenous levels of RPGRIP1L at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed with relatively high level of expression in hypothalamus and islet. During early development, expressed in multiple organs including brain, eye, forelimb and kidney.
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell junction, tight junction . In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions. Localizes to the ciliary transition zone. .
功能
Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) . May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis (By similarity). Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis . Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins (By similarity). Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2 (By similarity).
