产品名称
TMPRSS4 Rabbit Polyclonal Antibody
基因名称
TMPRSS4 TMPRSS3 UNQ776/PRO1570
蛋白名称
Transmembrane protease serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (CAPH2) (Membrane-type serine protease 2) (MT-SP2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56649
Human Swissprot No.
Q9NRS4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NRS4
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=214523
Mouse Swissprot No.
Q8VCA5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VCA5/entry
特异性
This antibody detects endogenous levels of TMPRSS4 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract (PubMed:10825129). Coexpressed with ACE2 within mature enterocytes (PubMed:32404436).
细胞定位
Cell membrane ; Single-pass type II membrane protein .; [Transmembrane protease serine 4 catalytic chain]: Secreted . Activated by cleavage and secreted. .
功能
Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity . Seems to be capable of activating ENaC (By similarity). ; (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry.
