产品名称
hIST1 Rabbit Polyclonal Antibody
蛋白名称
IST1 homolog (hIST1) (Putative MAPK-activating protein PM28)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9798
Human Swissprot No.
P53990
Human Swissprot Link
https://www.uniprot.org/uniprot/P53990
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=71955
Mouse Swissprot No.
Q9CX00
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CX00/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=307833
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q568Z6/entry
特异性
This antibody detects endogenous levels of hIST1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasmic vesicle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Nucleus envelope . Localizes to centrosome and midbody of dividing cells (PubMed:19129480, PubMed:19129479, PubMed:20719964). Colocalized with SPART to the ends of Flemming bodies during cytokinesis (PubMed:20719964). Localizes to the reforming nuclear envelope on chromatin disks during late anaphase. .
功能
ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation . Is required for efficient abscission during cytokinesis . Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells . During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing . Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 . Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST .
