产品名称
MKS3 Rabbit Polyclonal Antibody
蛋白名称
Meckelin (Meckel syndrome type 3 protein) (Transmembrane protein 67)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=91147
Human Swissprot No.
Q5HYA8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5HYA8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=329795
Mouse Swissprot No.
Q8BR76
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BR76/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P0C152/entry
特异性
This antibody detects endogenous levels of MKS3 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed in adult and fetal tissues. Expressed at higher level in spinal cord.
细胞定位
Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:22121117). .
功能
Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC).
