产品名称
CLPP Rabbit Polyclonal Antibody
蛋白名称
Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial (EC 3.4.21.92) (Endopeptidase Clp)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8192
Human Swissprot No.
Q16740
Human Swissprot Link
https://www.uniprot.org/uniprot/Q16740
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53895
Mouse Swissprot No.
O88696
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88696/entry
特异性
This antibody detects endogenous levels of CLPP at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney.
细胞定位
Mitochondrion matrix .
功能
Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates . Cleaves PINK1 in the mitochondrion .
