产品名称
PLOD3 Rabbit Polyclonal Antibody
蛋白名称
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8985
Human Swissprot No.
O60568
Human Swissprot Link
https://www.uniprot.org/uniprot/O60568
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26433
Mouse Swissprot No.
Q9R0E1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9R0E1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=288583
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U367/entry
特异性
This antibody detects endogenous levels of PLOD3 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous (PubMed:9724729). Detected in heart, placenta and pancreas and at lower levels in lung, liver and skeletal muscle (PubMed:9582318, PubMed:9724729).
细胞定位
Rough endoplasmic reticulum . Endoplasmic reticulum lumen . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Lumenal side . Secreted . Secreted, extracellular space . The majority of the secreted protein is associated with the extracellular matrix. .
功能
Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen . Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens . Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine . Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues . Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues . Essential for normal biosynthesis and secretion of type IV collagens (Probable). Essential for normal formation of basement membranes (By similarity).
