产品名称
HMGCR Rabbit Polyclonal Antibody
蛋白名称
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3156
Human Swissprot No.
P04035
Human Swissprot Link
https://www.uniprot.org/uniprot/P04035
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15357
Mouse Swissprot No.
Q01237
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q01237/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25675
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P51639/entry
特异性
This antibody detects endogenous levels of HMGCR at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
[Isoform 1]: Ubiquitously expressed with the highest levels in the cerebellum, fetal brain, testis, skin and adrenal gland. ; [Isoform 2]: Detected in the cerebellum, fetal brain, testis and adrenal gland. ; [Isoform 3]: Low abundance except in skin, esophagus, and uterine cervix.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Peroxisome membrane ; Multi-pass membrane protein .
功能
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis . HMGCR is the main target of statins, a class of cholesterol-lowering drugs .
