产品名称
CEP164 Rabbit Polyclonal Antibody
基因名称
CEP164 KIAA1052 NPHP15
蛋白名称
Centrosomal protein of 164 kDa (Cep164)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22897
Human Swissprot No.
Q9UPV0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UPV0
Mouse Swissprot No.
Q5DU05
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5DU05/entry
特异性
This antibody detects endogenous levels of CEP164 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in several cell lines.
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Nucleus. Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation (PubMed:26337392). Persisted at centrioles throughout mitosis. Expressed in chromatin-enriched nuclear fraction of HeLa cells. In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1. .
功能
Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
