产品名称
IMPDH2 Rabbit Polyclonal Antibody
蛋白名称
Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (IMPDH-II)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3615
Human Swissprot No.
P12268
Human Swissprot Link
https://www.uniprot.org/uniprot/P12268
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23918
Mouse Swissprot No.
P24547
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P24547/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/E9PU28/entry
特异性
This antibody detects endogenous levels of IMPDH2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor.
细胞定位
Cytoplasm . Nucleus . Cytoplasm, cytosol . Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine-nucleotide depletion. .
功能
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth . Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism . It may also have a role in the development of malignancy and the growth progression of some tumors.
