产品名称
IFT81 Rabbit Polyclonal Antibody
蛋白名称
Intraflagellar transport protein 81 homolog (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=28981
Human Swissprot No.
Q8WYA0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8WYA0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12589
Mouse Swissprot No.
O35594
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35594/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=373066
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P83829/entry
特异性
This antibody detects endogenous levels of IFT81 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in testis, moderately in ovary, heart, liver, skeletal muscle, kidney and pancreas, low in prostate, brain, placenta and lung and not detected in spleen, thymus, small intestine and colon. Isoform CDV-1R is abundantly expressed in testis.
细胞定位
Cell projection, cilium . Cytoplasm .
功能
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region . Required for ciliogenesis . Required for proper regulation of SHH signaling . Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella (By similarity).
