产品名称
RB1CC1 Rabbit Polyclonal Antibody
基因名称
RB1CC1 KIAA0203 RBICC
蛋白名称
RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9821
Human Swissprot No.
Q8TDY2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8TDY2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12421
Mouse Swissprot No.
Q9ESK9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ESK9/entry
特异性
This antibody detects endogenous levels of RB1CC1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells.
细胞定位
Nucleus . Cytoplasm . Cytoplasm, cytosol . Preautophagosomal structure . Lysosome . Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. .
功能
Involved in autophagy . Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 . Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways . Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor . Is a potent regulator of the RB1 pathway through induction of RB1 expression . Plays a crucial role in muscular differentiation . Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).
