产品名称
Annexin II (PTR1321) Mouse Monoclonal Antibody
别名
Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)
基因名称
ANXA2 ANX2 ANX2L4 CAL1H LPC2D
蛋白名称
Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.05% proclin 300.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=302
Human Swissprot No.
P07355
Human Swissprot Link
https://www.uniprot.org/uniprot/P07355
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12306
Mouse Swissprot No.
P07356
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P07356/entry
特异性
This antibody detects endogenous levels of Annexin II at Human, mouse, rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Secreted, extracellular space, extracellular matrix, basement membrane . Melanosome . In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
功能
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 .
