产品名称
HDAC1 (PTR1326) Mouse Monoclonal Antibody
别名
Histone deacetylase 1 (HD1) (EC 3.5.1.98)
蛋白名称
Histone deacetylase 1 (HD1) (EC 3.5.1.98)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.05% proclin 300.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3065
Human Swissprot No.
Q13547
Human Swissprot Link
https://www.uniprot.org/uniprot/Q13547
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=433759
Mouse Swissprot No.
O09106
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O09106/entry
特异性
This antibody detects endogenous levels of HDAC1 at Human, mouse, rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
功能
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events . Histone deacetylases act via the formation of large multiprotein complexes . Also functions as deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3 and TSHZ3 . Deacetylates SP proteins, SP1 and SP3, and regulates their function . Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons . Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation . Deacetylates TSHZ3 and regulates its transcriptional repressor activity . Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B . Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity . Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones .
