产品名称
Smad1/9 (PTR2351) Mouse Monoclonal Antibody
蛋白名称
Mothers against decapentaplegic homolog 1 (MAD homolog 1/9) (Mothers against DPP homolog 1/9) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1/9) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
反应种属
Human, Rat (predicted: Mouse)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4086
Human Swissprot No.
Q15797
Human Swissprot Link
https://www.uniprot.org/uniprot/Q15797
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17125
Mouse Swissprot No.
P70340
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P70340/entry
特异性
This antibody detects endogenous levels of Smad1/9 at Human, Predict react with Mouse, Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Highest expression seen in the heart and skeletal muscle.
细胞定位
Cytoplasm . Nucleus . Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity). .
功能
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
