BD-PM4732

GSK3α/β (PTR2350) Mouse Monoclonal Antibody

常规抗体

GSK3A GSK3B

Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) GSK3α;GSK3 A; GSK3 B; GSK3 alphal; GSK3 beta; GSK3 β ;GSK3β

WB

Human (predicted: Mouse, Rat)

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

2931

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2931

P49840

https://www.uniprot.org/uniprot/P49840

606496

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=606496

Q2NL51

https://www.uniprot.org/uniprotkb/Q2NL51/entry

This antibody detects endogenous levels of GSK3α/β at Human, Predict react with Mouse, Rat

WB 1:500-2000

55kD

-15°C to -25°C/1 year(Do not lower than -25°C)

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 . Requires primed phosphorylation of the majority of its substrates . Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis . Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors . In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin . Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease . May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions which activates KAT5/TIP60 acetyltransferase activity and promotes acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer . Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR .

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