BD-PN1088

KCNS3 Rabbit Polyclonal Antibody

常规抗体

KCNS3

Potassium voltage-gated channel subfamily S member 3 (Delayed-rectifier K(+) channel alpha subunit 3) (Voltage-gated potassium channel subunit Kv9.3)

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

3790

Q9BQ31

https://www.uniprot.org/uniprotkb/Q9BQ31/entry

Q8BQZ8

http://www.uniprot.org/uniprot/Q8BQZ8

O88759

http://www.uniprot.org/uniprot/O54941O88759

Synthesized peptide derived from human protein . at AA range: 300-380

KCNS3 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

54kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been

Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level) (PubMed:22943705). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung (PubMed:10484328).

Cell membrane ; Multi-pass membrane protein . May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 (PubMed:10484328). .

domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Potassium channel subunit. Modulates channel activity and reduces the ion flow.,similarity:Belongs to the potassium channel family. S subfamily.,subcellular location:May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.,subunit:Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins.,tissue specificity:Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.