产品名称
RRAD (PTR2260) Mouse Monoclonal Antibody
别名
GTP-binding protein RAD (RAD1) (Ras associated with diabetes)
蛋白名称
GTP-binding protein RAD (RAD1) (Ras associated with diabetes)
反应种属
Human, not react with Mouse, Rat
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.05% proclin 300.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6236
Human Swissprot No.
P55042
Human Swissprot Link
https://www.uniprot.org/uniprot/P55042
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=0
Mouse Swissprot No.
O88667
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88667/entry
特异性
This antibody detects endogenous levels of RRAD at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.
功能
May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
