产品名称
Vitamin D Receptor (PTR2542) Mouse Monoclonal Antibody
别名
Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)
蛋白名称
Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)
存储缓冲液
PBS, pH7.4, 50% glycerol, 0.03%Proclin 300
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7421
Human Swissprot No.
P11473
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P11473/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22337
Mouse Swissprot No.
P48281
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P48281/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24873
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P13053/entry
特异性
This antibody detects endogenous levels of Vitamin D Receptor at Human
稀释度
WB 1:500-2000 ELISA 1:5000-20000
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Cytoplasm . Localizes mainly to the nucleus (PubMed:28698609, PubMed:12145331). Localization to the nucleus is enhanced by vitamin D3. .
功能
caution:It is uncertain whether Met-1 or Met-4 is the initiator.,disease:Defects in VDR are the cause of type IIA rickets [MIM:277440]; also known as hypocalcemic vitamin D-resistant rickets (HVDRR). HVDRR is most frequently an autosomal recessive disorder characterized by severe rickets, hypocalcemia and secondary hyperparathyroidism.,domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.,online information:The Singapore human mutation and polymorphism database,polymorphism:Genetic variations in VDR may determine Mycobacterium tuberculosis susceptibility [MIM:607948].,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF.,
