产品名称
c-MYC (PTR2340) Mouse Monoclonal Antibody
别名
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
蛋白名称
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
反应种属
Human (predicted: Mouse, Rat)
存储缓冲液
PBS, pH7.4, 50% glycerol, 0.03%Proclin 300
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4609
Human Swissprot No.
P01106
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P01106/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17869
Mouse Swissprot No.
P01108
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P01108/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24577
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P09416/entry
特异性
This antibody detects endogenous levels of c-MYC at Human, Mouse,Rat
稀释度
WB 1:500-2000 ELISA 1:5000-20000
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus, nucleoplasm . Nucleus, nucleolus .
功能
disease:A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.,disease:Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.,function:Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.,online information:Myc entry,PTM:Phosphorylated by PRKDC.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B.,
