产品名称
MGMT (PTR2300) Mouse Monoclonal Antibody
蛋白名称
Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
P16455
Human Swissprot Link
https://www.uniprot.org/uniprot/P16455
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17314
Mouse Swissprot No.
P26187
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P26187/entry
特异性
This antibody detects endogenous levels of MGMT at Human, Predict react with Mouse;Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
