产品名称
GLUT-1 (PTR2138) Mouse Monoclonal Antibody
蛋白名称
Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)
反应种属
Human (predicted: Mouse, Rat)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6513
Human Swissprot No.
P11166
Human Swissprot Link
https://www.uniprot.org/uniprot/P11166
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20525
Mouse Swissprot No.
P17809
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P17809/entry
特异性
This antibody detects endogenous levels of GLUT-1 at Human, Predict react with Mouse, Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues.
细胞定位
Cell membrane ; Multi-pass membrane protein . Melanosome . Photoreceptor inner segment . Localizes primarily at the cell surface (PubMed:18245775, PubMed:19449892, PubMed:23219802, PubMed:25982116, PubMed:24847886). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .
功能
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake . Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses . Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain . In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).
