BD-PM4442

EGFR (PTR2121) Mouse Monoclonal Antibody

EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1

常规抗体

EGFR

Epidermal growth factor receptor

WB

Human

PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.

1956

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1956

P00533

http://www.uniprot.org/uniprotkb/P00533/entry

13649

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13649

Q01279

http://www.uniprot.org/uniprot/Q01279

http://www.uniprot.org/uniprot/

The antibody detects endogenous EGFR proteins.

WB 1:1000

175kD

-15°C to -25°C/1 year(Do not lower than -25°C)

Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.

Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). .; [Isoform 2]: Secreted.

MAPK_ERK_Growth;MAPK_G_Protein;ErbB_HER;Calcium;Cytokine-cytokine receptor interaction;Endocytosis;Dorso-ventral axis formation;Focal adhesion;Adherens_Junction;Gap junction;Regulates Actin and Cytoskeleton;GnRH;Epithelial cell signaling in Helicobacter p

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in EGFR are associated with lung cancer [MIM:211980].,function:Isoform 2/truncated isoform may act as an antagonist.,function:Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with C-SRC and CTNNB1/beta-catenin.,miscellaneous:Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.,online information:EGFR entry,PTM:Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.,PTM:Phosphorylation of Ser-695 is partial and occurs only if Thr-693 is phosphorylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds RIPK1. CBL interacts with the autophosphorylated C-terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1. Binds MUC1.,tissue specificity:Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.,

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