产品名称
Glial Fibrillary Acidic Protein (GFAP) (PTR2201/470) Mouse Monoclonal Antibody
别名
wu:fb34h11
ALXDRD
cb345
etID36982.3
FLJ42474
FLJ45472
GFAP
GFAP_HUMAN
gfapl
Glial fibrillary acidic protein
Intermediate filament protein
wu:fk42c12
xx:af506734
zgc:110485
反应种属
Human, Mouse (predicted: Rat)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2670
Human Swissprot No.
P14136
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P14136/entry
特异性
The antibody can specifically recognize human GFAP protein.
稀释度
IHC-p 1:200-400, WB 1:200-1000
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in cells lacking fibronectin.
细胞定位
Cytoplasm . Associated with intermediate filaments. .
功能
alternative products:Isoforms differ in the C-terminal region which is encoded by alternative exons,disease:Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.,function:GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.,online information:GFAP entry,similarity:Belongs to the intermediate filament family.,subcellular location:Associated with intermediate filaments.,subunit:Interacts with SYNM (By similarity). Isoform 3 interacts with PSEN1 (via N-terminus).,tissue specificity:Expressed in cells lacking fibronectin.,
