产品名称
uPAR (PT2194) Mouse Monoclonal Antibody
蛋白名称
Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87)
反应种属
Human,CHLAE,Not Mouse,Rat
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5329
Human Swissprot No.
Q03405
Human Swissprot Link
https://www.uniprot.org/uniprot/Q03405
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18793
Mouse Swissprot No.
P35456
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P35456/entry
特异性
This antibody detects endogenous levels of uPAR at H,CHLAE;Not M,R
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
细胞定位
Cell membrane . Cell projection, invadopodium membrane . Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. .; [Isoform 1]: Cell membrane ; Lipid-anchor, GPI-anchor .; [Isoform 2]: Secreted .
功能
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
