产品名称
TGF β1 (PT2173) Mouse Monoclonal Antibody
别名
Transforming growth factor beta-1 (TGF-beta-1) [Cleaved into: Latency-associated peptide (LAP)]
蛋白名称
Transforming growth factor beta-1 (TGF-beta-1) [Cleaved into: Latency-associated peptide (LAP)]
反应种属
Human, Mouse (predicted: Rat)
存储缓冲液
PBS, pH7.4, 50% glycerol, 0.03%Proclin 300
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7040
Human Swissprot No.
P01137
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P01137/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21803
Mouse Swissprot No.
P04202
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P04202/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59086
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P17246/entry
特异性
This antibody detects endogenous levels of TGF β1 at Human, Mouse,Rat
稀释度
WB 1:500-2000 IHC 1:100-300 ELISA 1:5000-20000
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158).
细胞定位
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix .; [Transforming growth factor beta-1]: Secreted .
功能
disease:Defects in TGFB1 are the cause of Camurati-Engelmann disease (CED) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CED is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.,function:Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.,induction:Activated in vitro at pH below 3.5 and over 12.5.,online information:TGF beta-1 entry,polymorphism:In post-menopausal Japanese women, the frequency of Leu-10 is higher in subjects with osteoporosis than in controls.,PTM:Glycosylated.,PTM:The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.,similarity:Belongs to the TGF-beta family.,subunit:The inactive form consists of a TGFB1 homodimer non-covalently linked to a latency-associated peptide (LAP) homodimer. The inactive complex can contain a latent TGFB1-binding protein. The active form is a homodimer of mature TGFB1; disulfide-linked. Heterodimers of TGFB1/TGFB2 have been found in bone. Interacts with CD109 and DPT.,tissue specificity:Highly expressed in bone.,
