产品名称
CREBBP (PT0619) Mouse Monoclonal Antibody
蛋白名称
CREB-binding protein (EC 2.3.1.48)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1387
Human Swissprot No.
Q92793
Human Swissprot Link
https://www.uniprot.org/uniprot/Q92793
Mouse Swissprot No.
P45481
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P45481/entry
特异性
This antibody detects endogenous levels of CREBBP at Human, Predict react with Mouse, Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.
功能
Acetylates histones, giving a specific tag for transcriptional activation . Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 . Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers . Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) . Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region . Acetylates DDX21, thereby inhibiting DDX21 helicase activity . Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) . Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway .
